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NeuigkeitenPresentations of MikroLab GmbH at the CHICA National Education Conference, May 29 – June 03, 2010 in Vancouver, Canada:Recent research results were presented as posters in Vancouver: STEINMANN, J. Virological requirements of hand antiseptics – the choice of test viruses in Europe. STEINMANN, J., S. CIESEK, M. FRIESLAND, B. BECKER, J. STEINMANN, Th. PIETSCHMANN, E. STEINMANN. Inactivation and Stability of Hepatitis C Virus.
Representation of MikroLab GmbH at the APIC 36th Annual Educational Conference & International Meeting, June 7 - 11, 2009 in Fort Lauderdale, Florida:Recent research results were presented as Posters in Fort Lauderdale, Florida:
Murine norovirus: a new surrogate virus for human noroviruses?Human Noroviruses (NoVs) are the leading cause of viral gastroenteritis in health care facilities, hotels and many other public settings. In the past, the inactivation of these viruses by chemical agents was studied with the Feline Calicivirus (FCV) as surrogate, since human NoV cannot be grown in cell culture.In 2003, a Murine Norovirus (MNV) was isolated from a colony of immune deficient mice by Karst et al., named MNV-1. Recently, the MNV-1 was described as the first NoV that could be propagated in cell culture. MNV could serve instead of FCV as a surrogate virus for human noroviruses in testing chemical disinfectants. FCV, which has been used so far, does not belong to the genus norovirus but to the genus vesivirus and is therefore genetically not so closely related to the human noroviruses as the MNV (see phylogenetic tree). In summary, the MNV may become a useful model for the human Norovirus, meaning the test virus in inactivation studies may be changed from FCV to MNV as surrogate for human NoV in the future.
Revision of EN 14476The Virus Task Group and the WG 1 decided to revise the EN 14476. The draft of the EN 14476 in revision will be published soon. The most important points: hand rubs have to be tested in clean conditions, whereas hand wash formulations in dirty conditions. Furthermore, ready-to-use products can be additionally tested as 97% solution. Murine Norovirus strain S99 will be a test virus in the EN 14476 in the future. Comparative studies of poliovirus type 1, hepatitis A virus (HAV), Echovirus 1 and bovine enterovirus type 1 (ECBO)Eradication of poliomyelitis worldwide makes it necessary to replace poliovirus type 1 Lsc-2ab since the biosafety level of this currently used test virus will elevate. The ideal candidate should express the following properties:Apathogen or vaccination possibleAt the moment, hepatitis A virus (HAV), Echovirus 1 and bovine enterovirus type 1 (ECBO) are discussed as candidates. Comparative studies with the poliovirus type 1 and the new candidates must be started before any decision can be made.
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